Thursday, November 1, 2012

Happy National Down syndrome Awareness Week!

The 31 for 21 and Down syndrome Awareness Month may be over, but here in Canada, National Down syndrome Awareness week has just begun.

With the 31 for 21, we promote awareness and advocate for those with Down syndrome.  This week is about celebrating with people with DS and how they contribute to our everyday lives.

My son is a little small for self advocacy yet, but he constantly inspires me to want to learn more. 


Medical Mondays

Teaching Tuesdays
1 Welcome to the 31 for 21
2 ABHDS #4 - Roots of Institutionalization and Eugenics
8 Thyroid Disorders and DS
9 Signing and Language Development in DS
15 The Brain #1 - How the Brain Works
16 Learning and Down syndrome
22 The Brain #2 - The Brain and Trisomy 21
23 ABHDS #5 - From Education to Eugenics
29 The Brain #3 - DS, Alzheimers and a Very Special Mouse
30 ABHDS #6 - From Eugenics to Extermination


Wyatt & Zoe/Wordless Wednesdays



Therapy Thursdays
3 The Joys of Noise and Mess
4 To Sip or Not to Sip
10 Wordless Wednesday
11 All About the Crawl
17 Angels
18 Speech and Language #1
24 Autumn Babies
25 Speech and Language #2 - Early Intervention
31 In the News




Factoid Fridays



Storytime Saturdays
5 Fast Facts on DS (Revisited)
6 Telling Their Stories
12 We Want Respect
13 More Birth Stories
19 Special Needs Bullying
20 A Little Longer and a Little Different
26 DSM - "Mental Retardation" No Longer Acceptable
27 "Retarded"


Family Day/Silent Sundays



7 DS, Coping and Caregiver Stress


14 Care and Feeding of the "Special Needs" Parent


21 He Ain't Heavy...


28 Little Monsters




This year's campaign features Nicholas Popowich, a self advocate from Regina, Saskatchewan.  If you would like to know more about Nicholas or the National Down Syndrome Awareness Week, you can contact the Canadian Down syndrome Society.



Happy National Down syndrome Awareness Week 2012.  This week we "recognize and celebrate the contributions made by people with Down syndrome, like Nicholas, everyday in our schools, communities, workplaces and families." (CDSS, 2012)

Wednesday, October 31, 2012

In The News - October, 2012 (31 for 21, Day 31)

Every month I compile a list of the stories I post on Down Wit Dat's Facebook page. They are stories of activism, of inclusion, of advocacy, of education, of hope and of love.  These are from the month of October.

Legend:
AUDIOindicates an audio clip
APPEAL indicates an online petition or plea
BLOG indicates a blog post
EVENT indicates a scheduled event
LINKS indicates links or resource materials
PHOTOS indicates photos
STUDY indicates a study
THREAD indicates an online discussion thread
VIDEO indicates a video

BLOG
Join the 6th Annual 31 for 21 Challenge


BLOG
October's the new pink
BLOG
Coping With A Mealtime Monster
BLOG
BLOG
Kids with Ds

Makaton symbols and signs for Halloween.
LINKSTop 100 Special Needs Resources on the Web


Could Down's syndrome point the way to preventing Alzheimer's disease?

Henry's Fight for Inclusion
BLOG
I Don't Want Compassion for Kayla
BLOG
On beauty
BLOG
Down Syndrome, Off The Clock


VIDEO
Katy Perry performs a duet with a girl with autism.


Down syndrome baby's family finds support


Adults with Down Syndrome urged to vote


An Open Letter to Ann Coulter

My Special Child: Man Proves Life Down Syndrome Can be Fulfilling




NIH establishes Down syndrome patient registry


BLOG Spread the Word to stop the R Word
BLOG
Downs Syndrome Awareness Month #DSAM2012

One step closer with a Down syndrome patient registry
BLOG Carter's Story

Man with Down syndrome wins right to vote

Special needs: Friends find it hard to complain around me




Down Wit Dat has placed #9 in Circle of Moms' Top 25 Canadian Moms!  Thanks to all who voted! 

Top Special Needs Site

October is finally over;  thanks to everyone that supported me through this year's 31 for 21 Blogging Challenge.  It was a busy month; not only did I blog every single day, but I managed to work full time, work 25 hours of overtime, help keep three boisterous kids fed and dressed and still managed to avoid the cold that everyone seems to have.  A special thanks to my husband, who put up with proofreading and my self-imposed deadline crabbiness.  

On a more personal note, today is our 15th wedding anniversary (yes, on Hallowe'en).  Happy Anniversary honey!  I love you.



This month, our Medical Monday posts were featured on Downs Side Up.  Thanks Hayley!


We had our eighth T-21 Blog Hop on October 21. Join us for three days of excellent blogging on November 21! 

Our Facebook page is approaching 900 fans! Welcome to all our new friends. Please share!

Don't forget our Facebook Group!  Down Wit Dat - The Group is an all inclusive special needs discussion forum.  Join the conversation!

I'm looking forward to judging October's Photo Theme "Happy Hallowe'en!" Results to be posted tomorrow on Down Wit Dat's Facebook page. November's Theme to be announced at the same time.

...And that's the news.  Keep the stories and information coming!

A very Happy and safe Hallowe'en to you and your families!

 

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Tuesday, October 30, 2012

A Brief History of Down syndrome, Part 6: From Eugenics to Extermination

With the popularity of eugenic theories, the segregation and institutionalization of the differently abled and general public vilification, a fertile ground had been prepared for what came next.

A Call for Euthanasia

Many countries followed America's eugenics movement and imitated it's legislation.  In countries such as France, Belgium, Sweden, England and Germany, eugenic principles were introduced into everyday life.  Many US states had passed sterilization laws, Indiana being the first in 1907.

The 1912 International Eugenics Congress featured a paper called "Preliminary Report of the Committee of the Eugenic Section of the American Breeders' Association to Study and to Report on the Best Practical Means for Cutting Off the Defective Germ-Plasm in the Human Population", in which ten solutions were put forth to deal with the "socially unfit".  They were, in order:  Life segregation (or segregation during the reproductive period), Sterilization, Restrictive Marriage laws and customs, Eugenic Education of the public and of prospective marriage mates, Systems of matings purporting to remove defective traits, General environmental betterment, Polygamy, Euthanasia, Neo-Malthusian doctrine, artificial interference to prevent conception and Laissez-faire. An 1918 Eugenics Textbook "Applied Eugenics" by Paul Popenoe and Roswell H. Johnson, listed many suggestions as well, among which:
"... the first method which presents itself is execution. This has been used since the beginning of the race, very probably, although rarely with a distinct understanding of its eugenic effect; and its value in keeping up the standard of the race should not be underestimated."
American eugenicists felt that American society was not ready yet to implement organized euthanasia, however many institutions and physicians within employed their own methods.  Passive methods included allowing infants to starve to death (such as famed MD and wanna-be-movie star Harry J Haiselden) and withholding treatment. One large institution in Illinois however, fed it's patients tuberculosis infected milk believing that the genetically superior inmates would have immunity.  That particular institution, not surprisingly, had a 30 to 40 percent death rate per year.  Sterilization remained the most popular method;  in the first year of California's sterilization legislation for example, 9,782 people were sterilized.  Most of these were women.

Charles Davenport, author of Eugenics, The Science of Human Improvement by Better Breeding and one of the creators of the Eugenics Record Office (with funding from the estate of railroad baron E. H. Harriman) was particularly close with his German colleagues; even after America was in the grips of the Great Depression, American charities such as the Carnegie Institute and Rockefeller Foundation continued to fund German eugenics research.   However, the eugenics world continued to watch closely the American "accomplishments" of "biological courts", involuntary sterilization, segregation, detention, propaganda, perpetuating of pseudo-science and the ongoing discussion of euthanasia.

In 1924, an imprisoned corporal of the German Army began to study eugenic writings, including those of Davenport, Popenoe, Leon Witney and Madison Grant, who blamed the corruption of the Nordic ideal on Jews, Slavs, Afro-Americans and many others who were not blonde or blue eyed.  In his book The Passing of the Great Race or The Racial Bias of European History, Grant wrote:
"Mistaken regard for what are believed to be divine laws and a sentimental belief in the sanctity of human life, tend to prevent both the elimination of defective infants and the sterilization of such adults as are themselves of no value to the community. The laws of nature require the obliteration of the unfit, and human life is valuable only when it is of use to the community or race."  
"You are bearing this too".  Courtesy of H. E. A. R. T.
The young corporal, Adolf Hitler, went on to write fan mail to both Whitney and Grant. Hitler's letter to Grant thanked him for his book and referred to it as "my bible". In his own book, Mein Kampf, published shortly thereafter, Hitler echoed his eugenics heroes with the following call for euthanasia:
"The demand that defective people be prevented from propagating equally defective offspring is a demand of the clearest reason and if systematically executed represents the most humane act of mankind. It will spare millions of unfortunates undeserved sufferings, and consequently will lead to a rising improvement of health as a whole."
He also references the United States frequently, including his his admiration of restricting immigration.  His keen interest in American eugenics legislation is reflected in this comment to a comrade;
Nazi Eugenics propaganda poster from 1939,
stating "We Do Not Stand Alone"
"...it is possible to a large extent to prevent unhealthy and severely handicapped beings from coming into the world. I have studied with interest the laws of several American states concerning prevention of reproduction by people whose progeny would, in all probability, be of no value or be injurious to the racial stock."
Adolf Hitler came to power on January 30, 1933.  For the first 10 years of the 12 year Reich, eugenicists welcomed his proposed fulfillment of their tenets of identification, segregation, sterilization, eugenic courts and euthanasia.  In July of 1933, Germany passed the "Law for the Prevention of Heriditarily Diseased Offspring".  This law provided legal grounds for the sterilization of people deemed by a court hearing to be "unfit".  This law provided that any person with a hereditary disease could be sterilized if there was a high probability of it being passed on to future generations.  Those listed included "Congenital Mental Deficiency" (such as Down syndrome), schizophrenia, bipolar disorder, epilepsy, Huntington's chorea, blindness, deafness, any severe deformity and those with severe alcoholism.  In the general public, the notion of the "useless eater" was perpetuated.

Children at the Schönbrunn Psychiatric Hospital, 1934.
(Bundesarchiv, Bild 152-04-28 / Friedrich Franz Bauer / CC-BY-SA\)
In 1934, the superintendent of Virgina's Western State Hospital complained in the local paper "The Germans are beating us at their own game".   For years, Nazi doctors would continue to routinely consult with eugenicists across America.

Extermination and Aktion T4

The first incidence of state performed euthanasia in Germany was known as the "Child K" case.  Hitler was approached by the parents of a "deformed" child and asked his permission to allow the child to be put to death.  After consulting with his personal physician and chancellor, Hitler granted the child's doctor the ability to euthanize the child.

This poster proclaims “Sterilization is liberation, not
a punishment.”
and asks “Who would want to be
responsible for this?”
and features three children
with disabilities.  Photo courtesy of Calvin College
By August 18th 1939, Hitler had created the Reich Committee for the Scientific Registering of Serious Hereditary and Congenital Illnesses (Reichsausschuss zur wissenschaftlichen Erfassung erb- und anlagebedingter schwerer Leiden) which required mandatory registration of all births of developmentally delayed and handicapped children by doctors and midwives.  Children up to three years of age had to be reported to the offices of  the Reich Health Ministry. Code named Aktion T4, Hitler ordered the "mercy killing" of all deemed "life unworthy of life";  this plan focused initially on newborns and young children. The program was managed by Hitler's personal physician, Karl Brandt and the chief of Hitler's private chancellery, Philipp Bouler (the same two whose counsel he sought with Child K). To be included in this program were those with "idiocy and mongolism" (Down syndrome), those with blindness and deafness, microcephaly, hydrocephalus, absence of limbs, mid line defects of the head and spine and paralysis (such as cerebral palsy).  The decision to end a child's life was based on the results of a questionnaire.  No medical examination took place or records were consulted.  Three "medical experts" placed a red + or a blue - on a form marked "treatment".  A minus sign represented a decision by an "expert" to not kill the child.  Three plus signs meant the issue of a euthanasia warrant and transfer to a "Children's Specialty Department".  A unanimous decision was required;  in the event of a split decision, the child was "observed" for a period of time and another attempt would be made to achieve a consensus.

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"Life unworthy of life"

These children were sent to one of six facilities where they were killed by drugs or by starvation.  It is belived that 8,000 children were to lose their lives this way.  In October of the same year, this decree was extended to include older children and adults.  Hitler backdated his declaration to September first and increased the power of
"the authority of certain physicians to be designated by name in such manner that persons who, according to human judgment, are incurable can, upon a most careful diagnosis of their condition of sickness, be accorded a mercy death." 
This would not only dispose of the "useless eaters" but also free up beds in hospitals for wounded Nazi soldiers.  Questionnaires were sent to institutions for the mentally ill, chronically ill and hospitals.  Patients were required to be reported if they had schizophrenia, epilepsy, dementia, paralysis, syphillis, developmental delays, encephalitis, neurological conditions, had been in hospital or institutionalized for 5 years or more, was criminally insane, was a foreigner or was Jewish, African-American or Gypsy.

Tiergartenstraße 4, Courtesy of H. E. A. R. T.
There were four main divisions that aided the program that were created in 1939.  The first, the Reichsarbeitsgemeinschaft Heil- und Pflegeanstalten (RAG) was responsible for the distribution and return of the registration forms to the institutions.  The completed forms were forwarded to the "experts" who decided the patients fate.  The Gemeinnützige Krankentransport GmbH" (Gekrat)  was charged with transporting the patients via Gekrat buses to the killing centres, while the Gemeinnützige Stiftung für Anstaltspflege" (Stiftung) created extermination sites by renting spaces, setting up the equipment, hiring staff and managing their budgets.  Finally the  Zentralverrechnungsstelle Heil- und Pflegeanstalten" (ZVST) served as the central clearing office.  The main office was located in Berlin on Tiergartenstraße 4, which gave the program it's name of "T4".  Physicians and medical assistants were eager to assist with this programme as the salaries were made very attractive.

Six main euthenasia sites were created across Germany and Austria.  In January 1940, Brandenburg (near Berlin), Grafeneck (near Stuttgart) and Hartheim (near Linz, Austria) were established;  both Brandenburg and Grafeneck ceased functioning (officially) between September and December of the same year.  Sonnenstin/Pirna (near Dresden) opened in April of 1940 and Bernberg (near Magdeburg) was established in September.  The last to open was Hadamar (near Koblenz) which opened in January the following year (and closed that August).  Bernburg ceased operation in April 1943, while Sonnenstein/Pirna ended in August 1943.  Hartheim was the last to cease it's operation, which it did officially in December of 1944. The Zwischenanstalten were intermediate stops between the patients institution of origin and the killing centres.  They also managed the capacity of the centres and were tasked with 'cover up' for inquiring relatives. It was at Brandenburg, a converted prison, that the first Nazi gas exterminations took place. The T4 victims were gassed in chambers disguised as showers and their remains burned in giant ovens. Families were told that the victims had died of various illnesses including pneumonia or heart failure.  They would each recieve an urn contianing mixed ashes.  The routine deception and gassing/cremation would be used again, only on a much larger scale.

The billowing chimney at Hadamar. Ashes with
human hair would rain down upon the townspeople.
Courtesy of H. E. A. R. T.
Although it was a top secret operation, Aktion T4 became difficult to hide, especially with the dwindiling numbers of the mentally or physically disabled and mentally ill.  Also, the thick, constant, maloderous plumes of smoke from the crematoriums was also difficult to conceal.  It is rumoured that at Haldamar, a former hospital for the mentally ill, children would watch the incoming buses and taunt the inhabitants with "here are some more to be gassed".   Ashes containing human hair would rain down on the town.  Those aware of the goings-on at the six centers were either in favour of the program or completely silenced by fear.

The following three testimonials speak volumes about the killing centres (in this case, Hadamar):
“After doors were closed, the air was sucked out of the gas chamber through a ventilator by the same doctor who carried out the earlier `examination.’ Then for about ten minutes, carbon monoxide was let in [by that doctor] and its effect observed through a small window. As soon as he thought that those shut in had died, he had the gas chamber emptied. First fresh air was introduced through the ventilator, and the gas was forced out. From the beginning of the gassing until the reopening of the gas chamber took about one hour. The corpses that were to be dissected were removed to a special room. However, the great majority of corpses were immediately taken to the ovens and burned there.”
"Through it I saw 40-45 men who were pressed together in the next room and were now slowly dying. Some lay on the ground, others had slumped down, many had their mouths open as if they could not get any more air. The form of death was so painful that one cannot talk of a humane killing, especially since many of the dead men may have had moments of clarity. I watched the process for about 2-3 minutes and then left because I could no longer bear to look and felt sick.”
“Did I ever watch a gassing? Dear God, unfortunately, yes. And it was all due to my curiosity.... Downstairs on the left was a short pathway, and there I looked through the window.... In the chamber there were patients, naked people, some semi-collapsed, others with their mouths terribly wide open, their chests heaving. I saw that, I have never seen anything more gruesome. I turned away, went up the steps, upstairs was a toilet. I vomited everything I had eaten. This pursued me days on end.... Looking into the chamber, I could not imagine that this was completely without pain. Of course, I am a layman and this is just my opinion. A few were lying on the ground. The spines of all the naked people protruded. Some sat on the bench with their mouth wide open, their eyes wide open, and breathing with difficulty.”
[Testimonials courtesy of H. E. A. R. T]

A Catholic Bishop in Münster, named Clemens von Galen, delivered a sermon on August 3, 1941 which denounced Aktion T4 as murder.  The Nazi party was publicly condemned and the faithful encouraged to withdraw from the party due to their "ungodly" policies.  Hitler officially suspended the program 20 days later and in retaliation, beheaded three priests.  At that point, over 70 000 lives had been ended.  Although it had officially been stopped, it continued quietly in the background, especially in the hospitals of conqured territories and for those that remained in the institutions.  Instead of gas, patients were poisoned or starved to death.  Physicians were encouraged to err on the side of death when considering such an action.

The gas chambers used in the euthanasia centres were a testing ground;  the Nazi party used the Aktion T4 experience to aid in the construction of the death camps in places such as Auschwitz and Treblinka.  In fact, many SS officers that participated in the killing centres would go on to command in the camps.  Although officially abandoned, Aktion T4 was still considered a "success" and became the opening chapter in what would become the Holocaust.

Meanwhile, in the Allied countries, increasing numbers of institutional workers were being drafted, leaving the already overcrowded conditions even more destitute.  Although the horrors of the camps and Aktion T4 were exposed after the war, people continued to be sterilized against their will, long after eugenics was abandoned as a "science". In parts of Canada for example, this would continue well into the 1970's.

[Next time:  Abandonment and Abuse]


Black, Edwin. War Against the Weak: Eugenics and America's Campaign to Create a Master Race. New York: Four Walls Eight Windows, 2003. Print.

"Disability History Exhibit." Disability History Panels. Alaska Department of Health and Social Services, n.d. Web. <http://www.hss.state.ak.us/gcdse/history/HTML_Content_Main.htm>.

Grant, Madison. The Passing of the Great Race or The Racial Bias of European History. New York: Charles Scribner's Sons, 1916. Print.

Hitler, Adolf. Mein Kampf. Germany: Eher Verlag, 1925. Print.

Lifton, Robert J. The Nazi Doctors: Medical Killing and the Psychology of Genocide. New York: Basic, 2000. The Holocaust History Project. Web.

"Nazi Eugenics and Euthanasia." Holocaust Education & Archive Research Team. H. E. A. R. T., 2010. Web. <www.HolocaustResearchProject.org>.

Paralells in Time; A History of Developmental Disabilities, The Minnesota Governor's Council on Developmental Disabilities, 2012.

Popenoe, Paul, and Roswell H. Johnson. Applied Eugenics. New York: MacMillan, 1918. The Project Gutenberg EBook of Applied Eugenics. Project Gutenberg, 17 Oct. 2006. Web. <http://www.gutenberg.org/files/19560/19560-h/19560-h.htm>.

Van Wagenen, Bleeker, "Preliminary Report of the Committee of the Eugenic Section of the American Breeders' Association to Study and to Report on the Best Practical Means for Cutting Off the Defective Germ-Plasm in the Human Population" (2009). College of Law Faculty Publications. Paper 74. <http://digitalarchive.gsu.edu/col_facpub/74>


A Brief History of Down Syndrome: Part 1, Part 2, Part 3, Part 4, Part 5, Part 6, Part 7

Monday, October 29, 2012

Medical Monday: Down syndrome, Alzheimer Disease and a Very Special Mouse

In the last two posts for Medical Monday I have outlined the basic anatomy of the brain and have given an overview of some of the differences between a typical brain and one with Down syndrome.  Today's post is about some of the research that is going on that concerns Down syndrome and why that is significant. 
One of the major areas affected by Down syndrome is the hippocampus, which is largely tasked with spacial skills and memory creation/consolidation.   As there are three copies of chromosome 21 with Down syndrome (Trisomy 21), one theory is that it is an over expression of specific genes which causes some of the major cognitive difficulties. 

If the specific genes themselves, cellular activity created by these genes or even a protein or compound secreted/lacking from the cells can be targeted, some of the cognitive problems with DS can be alleviated (or so the theory goes). Most of the study in this area however,  could not be accomplished without a very special mouse.


The Down syndrome Mouse Model

Photo courtesy of Stanford School of
Medicine, Down Syndrome Research Center
Most of today's research involves a type of mouse that has been bred to have many of the characteristics of DS that occurs in humans.  We share many genes with mice;  the mouse chromosome 16 contains 80% of the genes of the human chromosome 21 (including most of what is known as the DSCR or Down syndrome Critical Region).  Mice with a trisomy of chromosome 16 have been available for decades, however none survived very long.  With the creation of new mouse models that do survive, there is an ideal analog that reproduces fast and readily.  These mice share many features with human DS:  developmental delay, cranio-facial changes, learning issues, hyperactivity, weight problems and some behaviour issues.  However, it is not a perfect model as it does not cover all of the DSCR;  new mouse models will need to be developed in time.

Having a model to help understand things like cognition has proved to be infinitely helpful and has opened many new avenues of research into Down syndrome, cognition and aging.   Included are: the excitation/inhibition of certain neural pathways, restoring neuronal pathways, neurotransmitter restoration, sleep abnormalities and the discovery/reassignment of drugs for treatment (for more information regarding specific American projects, see this listing, courtesy of the Down Syndrome Research and Treatment Foundation.  For a Canadian listing, see the Down Syndrome Research Foundation).


Down Syndrome and Alzheimer Disease

Alzheimer Disease is the most common form of dementia and has a very early onset in the Down syndrome community.  As a result, these two areas of research are frequently joined;  finding out what mechanism causes Alzheimers could lead for a treatment for both the general population and those with DS.

Dr. William Mobley is a Distinguished Professor and Chair of the Department of Neurosciences at UCSD and the Executive Director of UCSD's Down Syndrome Center for Research and Treatment.  In this video, you can see Dr. Mobley discuss not only the mouse model that he uses in his research but also the link between Alzheimers and Down Syndrome and what these findings will mean for people with DS (from 6:26 on).

(Video courtesy of UCSD-TV)

Every person with DS will develop Alzheimers; 40% of the general population develop dementia, most of which will also have this disease.  This type of research not only affects people with Down syndrome, but also will benefit the larger population greatly as well.

More Information and Donating to DS Research

Sadly, Down syndrome research is chronically underfunded.


If you are interested in learning more or possibly participating or helping out DS research there are a variety of foundations through which you can do so (including the Down Syndrome Research Foundation in Canada and The Down Syndrome Research and Treatment Foundation in the US).

One of the more enjoyable organizations has been the DSRTF's +15 Campaign.  Not only do they offer up a voice for research, but they also raise funds for ongoing studies.  With a goal of increasing the cognitive abilities of those with Down syndrome 15 percent (which could mean the difference between a person living on their own or not, for example), they have a variety of ways in which to stay abreast of current research trends.  Interested parties can donate $15 (or more) directly to DS research or if you wish to "Adopt-a-Mouse", host an event or simply raise awareness, those options are available as well.
 
Understanding Down syndrome and increasing the cognitive abilities of those with it are very close to being a reality.  With ongoing research and new discoveries being made all the time, successful treatments could shortly be within our grasp. 




+15 <http://www.plus15.org/>

Down Syndrome Research Foundation <http://www.dsrf.org/>

Down Syndrome Research and Treatment Foundation <http://www.dsrtf.org/page.aspx?pid=291>

Jarrold, Christopher, Lynn Nadel, and Stefano Vicari. "Memory and Neuropsychology in Down Syndrome." Down Syndrome Education International (2007): n. pag. Web. <http://www.down-syndrome.org/>.


Heyn, Sietske. "The Down Syndrome Mouse - A Historical Perspective & What the Future May Hold." Stanford School of Medicine Down Syndrome Research Center. Stanford School of Medicine, n.d. Web. <http://med.stanford.edu/>.

Stanford School of Medicine, Down Syndrome Research Center <http://med.stanford.edu/>

UC San Diego School of Medicine, Department of Neurosciences  <http://neurosciences.ucsd.edu/Pages/default.aspx>

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